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Brief Job Details:
Job Title:
Postdoctoral Fellowship in Stem Cell Biology: Induced Pluripotent Stem Cells
Company Name:
MountSinai School of Medicine
Location:
New York NY 10029 USA
Application:
Job Description:
Postdoctoral Fellow positions are available at the Black Family Stem Cell Institute (BFSCI; Director, Ihor Lemischka, PhD), and Tisch Cancer Institute (TCI; Director, Steven Burakoff, MD), MountSinai School of Medicine, New York City in the laboratory of Margaret H. Baron, MD PhD to investigate reprogramming red blood cells to pluripotent stem cells.
A general focus of the lab is to understand how stem cells become specified along specific lineages such as hematopoietic and vascular. A postdoctoral position is available to study red blood cell (erythroid) development in differentiating mouse embryonic stem (ES) and induced pluripotent stem (iPS) cells. The project will utilize recently developed tools to isolate cells from these niches and (1) define the maturation pathway of ES cell-derived primitive erythroid cells and determine whether they undergo the full sequence of steps observed in vivo, (2) identify and isolate mouse and human ES cell-derived EryP progenitors, define their surface antigen expression, and develop methods for expanding their numbers in culture and (3) study the pluripotency of erythroblasts isolated at different stages of development. Experimental approaches will include classical cell and molecular biology techniques, small interfering RNA technologies, molecular profiling, chromatin immunoprecipitation (ChIP), genetic manipulation of mice, stem and progenitor cell culture, and transplantation into mice. Through the use of novel transgenic mouse and embryonic stem (ES) cell lines generated in our lab, we have made a number of unexpected observations about embryonic red blood cell development and are interested in comparing these cells with later erythroid lineages (fetal liver, adult bone marrow) and in studying the signals responsible for the formation and proliferation of their progenitors (see Blood 2006, 109:343 and Proc. Natl. Acad. Sci. 2008 105:6662). Through microarray analyses, we have identified a number of genes for further characterization using assays we have recently developed.
Interested applicants should be highly motivated, have a PhD and/or MD degree, a strong background in molecular biology, cell biology, or mouse genetics and publications in internationally recognized journals. Applicants should be fluent in English and be available for an interview. Please send a cover letter, brief description of research experience and interests, curriculum vitae and contact information for three references to Professor Margaret H. Baron.
